NF-X2 that binds to the DRA X2-box is activator protein 1. Expression cloning of c-Jun.
G Andersson, BM Peterlin - Journal of immunology (Baltimore, Md …, 1990 - journals.aai.org
Abstract Human class II MHC Ag are a family of cell surface glycoproteins. Their constitutive
expression is limited to B lymphocytes and thymic epithelial cells. In many other cells their
expression can be induced by IFN-gamma. Conserved upstream promoter sequences
regulate this tissue-specific expression of class II genes. In the DRA promoter, one of these
cis-acting regulatory motifs is the X2-box to which nuclear factor X2 (NF-X2) binds. Here, we
present the isolation and characterization of the full-length cDNA clone encoding NF-X2 …
expression is limited to B lymphocytes and thymic epithelial cells. In many other cells their
expression can be induced by IFN-gamma. Conserved upstream promoter sequences
regulate this tissue-specific expression of class II genes. In the DRA promoter, one of these
cis-acting regulatory motifs is the X2-box to which nuclear factor X2 (NF-X2) binds. Here, we
present the isolation and characterization of the full-length cDNA clone encoding NF-X2 …
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